解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Gene expression in eukaryotes is controlled by DNA sequences at promoter and enhancer regions, whose accessibility for binding by regulatory proteins dictates their specific patterns of activity. Here, we identify the protein Zbtb7a as a factor required for inducible changes in accessibility driven by transcription fa...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004526
更新日期:2018-05-29 00:00:00
abstract::For the last 100 years, it has been uncontroversial to state that the plant germline is set aside late in development, but there is surprisingly little evidence to support this view. In contrast, much evolutionary theory and several recent empirical studies seem to suggest the opposite-that the germlines of some and p...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005439
更新日期:2018-05-16 00:00:00
abstract::Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake. Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient receptor potential vanilloid 1 receptor (TRPV1)-like receptors. To s...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004399
更新日期:2018-04-24 00:00:00
abstract::Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (mtDNA) depletion, i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005707
更新日期:2018-04-18 00:00:00
abstract::Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without crea...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005019
更新日期:2018-04-16 00:00:00
abstract::It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of etomoxir, the proliferation rate of various cancer cells was unaffec...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003782
更新日期:2018-03-29 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.1002454.]. ...
journal_title:PLoS biology
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pbio.1002624
更新日期:2018-03-14 00:00:00
abstract::Meta-research is the study of research itself: its methods, reporting, reproducibility, evaluation, and incentives. Given that science is the key driver of human progress, improving the efficiency of scientific investigation and yielding more credible and more useful research results can translate to major benefits. T...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005468
更新日期:2018-03-13 00:00:00
abstract::Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to-or is selected by-this environment remains unclear. From previous studies, the parasites that cause...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004328
更新日期:2018-03-12 00:00:00
abstract::Transposable elements comprise a huge portion of most animal genomes. Unlike many pathogens, these elements leave a mark of their impact via their insertion into host genomes. With proper teasing, these sequences can relay information about the evolutionary history of transposons and their hosts. In a new publication,...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.2005470
更新日期:2018-03-05 00:00:00
abstract::Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized pr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003452
更新日期:2018-02-14 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...
journal_title:PLoS biology
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pbio.1002619
更新日期:2018-01-25 00:00:00
abstract::The Hippo pathway plays a key role in regulating cell turnover in adult tissues, and abnormalities in this pathway are consistently associated with human cancers. Hippo was initially implicated in the control of cell proliferation and death, and its inhibition is linked to the expansion of stem cells and progenitors, ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002399
更新日期:2018-01-22 00:00:00
abstract::The human body is a complex organism, the gross mechanical properties of which are enabled by an interconnected musculoskeletal network controlled by the nervous system. The nature of musculoskeletal interconnection facilitates stability, voluntary movement, and robustness to injury. However, a fundamental understandi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002811
更新日期:2018-01-18 00:00:00
abstract::Neuronal migration during embryonic development contributes to functional brain circuitry. Many neurons migrate in morphologically distinct stages that coincide with differentiation, requiring tight spatial regulation. It had been proposed that neurotransmitter-mediated activity could exert this control. Here, we demo...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002226
更新日期:2018-01-04 00:00:00
abstract::Developmental biology (including embryology) is proposed as "the stem cell of biological disciplines." Genetics, cell biology, oncology, immunology, evolutionary mechanisms, neurobiology, and systems biology each has its ancestry in developmental biology. Moreover, developmental biology continues to roll on, budding o...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003691
更新日期:2017-12-28 00:00:00
abstract::Sixty-five years after Turing first revealed the potential of systems with local activation and long-range inhibition to generate pattern, we have only recently begun to identify the biological elements that operate at many scales to generate periodic patterns in nature. In this Primer, we first review the theoretical...
journal_title:PLoS biology
pub_type: 杂志文章,评审
doi:10.1371/journal.pbio.2004412
更新日期:2017-12-20 00:00:00
abstract::Over the past 3 decades, in a series of studies on some of the most extensively studied toxic chemicals and pollutants, scientists have found that the amount of toxic chemical linked with the development of a disease or death-which is central to determining "safe" or "hazardous" levels-is proportionately greater at th...
journal_title:PLoS biology
pub_type: 社论
doi:10.1371/journal.pbio.2003066
更新日期:2017-12-19 00:00:00
abstract::From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate this, we used single-cell RNA sequencing to quantify transcript heterogeneity in single Saccharomyces cerevisiae cells treated with...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004050
更新日期:2017-12-14 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.1001326.]. ...
journal_title:PLoS biology
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pbio.1002616
更新日期:2017-12-11 00:00:00
abstract::The mammalian circadian clock and the cell cycle are two major biological oscillators whose coupling influences cell fate decisions. In the present study, we use a model-driven experimental approach to investigate the interplay between clock and cell cycle components and the dysregulatory effects of RAS on this couple...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002940
更新日期:2017-12-07 00:00:00
abstract::Rapidly grouping local elements into an organized object (i.e., perceptual integration) is a fundamental yet challenging task, especially in noisy contexts. Previous studies demonstrate that ventral visual pathway, which is widely known to mediate object recognition, engages in the process by conveying object-level in...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003646
更新日期:2017-11-30 00:00:00
abstract::Australia's iconic Great Barrier Reef (GBR) continues to suffer from repeated impacts of cyclones, coral bleaching, and outbreaks of the coral-eating crown-of-thorns starfish (COTS), losing much of its coral cover in the process. This raises the question of the ecosystem's systemic resilience and its ability to reboun...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003355
更新日期:2017-11-28 00:00:00
abstract::Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect of glutamine deficiency on cellular responses to DNA damage and chemotherapeutic treatment remains u...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002810
更新日期:2017-11-06 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2002794.]. ...
journal_title:PLoS biology
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pbio.1002615
更新日期:2017-11-01 00:00:00
abstract::Here, we present the use of ethoscopes, which are machines for high-throughput analysis of behavior in Drosophila and other animals. Ethoscopes provide a software and hardware solution that is reproducible and easily scalable. They perform, in real-time, tracking and profiling of behavior by using a supervised machine...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003026
更新日期:2017-10-19 00:00:00
abstract::Malaria transmission is known to be strongly impacted by temperature. The current understanding of how temperature affects mosquito and parasite life history traits derives from a limited number of empirical studies. These studies, some dating back to the early part of last century, are often poorly controlled, have l...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003489
更新日期:2017-10-16 00:00:00
abstract::Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox"). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), a simpl...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2001655
更新日期:2017-09-13 00:00:00
abstract::The Open Science Prize was established with the following objectives: first, to encourage the crowdsourcing of open data to make breakthroughs that are of biomedical significance; second, to illustrate that funders can indeed work together when scientific interests are aligned; and finally, to encourage international ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002617
更新日期:2017-08-01 00:00:00
abstract::From a research perspective, the interest in biobanking continues to intensify. Governments and industry have invested heavily in biobanks, as exemplified by initiatives like the United Kingdom Biobank and United States' Precision Medicine Initiative. But despite this enthusiasm, many profound legal and ethical challe...
journal_title:PLoS biology
pub_type: 杂志文章,评审
doi:10.1371/journal.pbio.2002654
更新日期:2017-07-25 00:00:00
abstract::The sperm's crucial function is to locate and fuse with a mature oocyte. Under laboratory conditions, Caenorhabditis elegans sperm are very efficient at navigating the hermaphrodite reproductive tract and locating oocytes. Here, we identify chemosensory and oxygen-sensing circuits that affect the sperm's navigational ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002047
更新日期:2017-06-29 00:00:00
abstract::Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002711
更新日期:2017-06-26 00:00:00
abstract::Ever since the discovery of neural stem cells in the mammalian brain, the possibility of brain tissue regeneration has captured the minds of scientists, clinicians, and the public. Neural stem cells have been envisioned as a source of donor cells for transplantation and vectors for the delivery of gene therapy. Over t...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002329
更新日期:2017-05-15 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2001154.]. ...
journal_title:PLoS biology
pub_type: 已发布勘误
doi:10.1371/journal.pbio.1002604
更新日期:2017-05-09 00:00:00
abstract::The fate of neural progenitor cells (NPCs) during corticogenesis is determined by a complex interplay of genetic or epigenetic components, but the underlying mechanism is incompletely understood. Here, we demonstrate that Suppressor of Mek null (Smek) interact with methyl-CpG-binding domain 3 (Mbd3) and the complex pl...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2001220
更新日期:2017-05-03 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2001951.]. ...
journal_title:PLoS biology
pub_type: 已发布勘误
doi:10.1371/journal.pbio.1002603
更新日期:2017-05-01 00:00:00
abstract::The issue of nonreplicable evidence has attracted considerable attention across biomedical and other sciences. This concern is accompanied by an increasing interest in reforming research incentives and practices. How to optimally perform these reforms is a scientific problem in itself, and economics has several scient...
journal_title:PLoS biology
pub_type: 杂志文章,评审
doi:10.1371/journal.pbio.2001846
更新日期:2017-04-26 00:00:00
abstract::Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster,...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2000862
更新日期:2017-04-25 00:00:00
abstract::Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the levels of plasma low-density lipoprotein cholesterol (LDL-C). Here, we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall around codon 34, mediated by the sequence of the nasc...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2001882
更新日期:2017-03-21 00:00:00
abstract::Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2000245
更新日期:2017-03-10 00:00:00